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shutterstock_NEW_333"NEW DRGUS Approval from FDA approves
new multiple sclerosis treatment: Tecfidera"
Written 11/04/2013/
The U.S. Food and Drug Administration today approved Tecfidera (dimethyl fumarate) capsules to treat adults with relapsing forms of multiple sclerosis (MS). MS is a chronic, inflammatory, autoimmune disease of the central nervous system that disrupts communication between the brain and other parts of the body. It is among the most common causes of neurological disability in young adults and occurs more frequently in women than men.
shutterstock_2222_NEWNew Drugs Market exploration of " soft gelatin capsules "
Written 27/04/2013/
Market exploration of " SOFTGEL" After more than 2 decade of continuous research and development soft gelatin capsule market is boom. Soft gelatin capsules or also known as soft gels are becoming a popular dosage form for the administration of liquids, suspensions, pastes, and dry powders in the dietary supplement industry. Softgels can be an effective delivery system for oral drugs, especially poorly soluble drugs. This is because the fill can contain liquid ingredients that help increase solubility or permeability of the drug across the membranes in the body. Liquid ingredients are difficult to include in any other solid dosage form such as a tablet. Development of soft gelatin capsule (softgel) dosage form is of growing interest for the oral delivery of poorly water soluble compounds (BCS class II or class IV). The soft gel dosage form offers several advantages over other oral dosage forms, such as delivering a liquid matrix designed to solubilize and improve the oral bio availability of a poorly soluble compound as a unit dose solid dosage form, delivering low and ultra-low doses of a compound, delivering a low melting compound, and minimizing potential generation of dust during manufacturing and thereby improving the safety of production personnel. However, due to the very dynamic nature of the softgel dosage form, its development and stability during its shelf-life are fraught with several challenges. The goal of the current review is to provide an in-depth discussion on the softgel dosage form to formulation scientists who are considering developing softgels for therapeutic compounds. The advantages of soft gelatin capsule : Soft gels are easy to swallow, once swallowed, release their contents very quickly. have the ability to mask odors and unpleasant tastes have an elegant appearance readily dissolve in the gastric juices of the digestive tract they may enhance the bioavailability of the active ingredient In specialized dosage form, soft gel can be made into chewable, extended release, captabs, etc. It can also be used for ophthalmic preparations, e.g. aplicaps, vaginal/rectal suppositories. Dosage Accuracy. Uniformity and precision dosage Product Security. Dosage and formulation are tamper-resistant (a punctured or tampered softgels will leak or become discoloured). Protection against counterfeit Product Stability. Sealed container, Protection from light for photosensitive formulations, Protects drug from oxidation and degradation